What has taken the malarial vaccines so long?

In the rise of antimicrobial resistance among pathogens and infectious diseases, vaccines are a potent global health solution. Vaccines mimic the pathogens to train the immune system. The training allows the immune system to be quickly activated in the event of a real infection by the pathogen. Notable recent examples are vaccines against COVID-19, a disease caused by SARS-CoV-2 viral infection. While this was one of the greatest achievements in the history of vaccine development, the quest for vaccines against many pathogens has been challenging, resulting in little success. Why has that been the case? I will take you through one such example that I study; the Plasmodium parasites that cause malaria.
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